InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HEMK1

Summary

InnateDB Protein

IDBP-37143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HEMK1

Protein Name

HemK methyltransferase family member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000232854

InnateDB Gene

IDBG-37141 (HEMK1)

Protein Structure

UniProt Annotation

Function

N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L. {ECO:0000269PubMed:18541145}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:18541145}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity

Biological Process

GO:0006306	DNA methylation
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0031167	rRNA methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000241 Putative RNA methylase domain
IPR002295 N6 adenine-specific DNA methyltransferase, D21 class
IPR004398 RNA methyltransferase, RsmD
IPR004556 Modification methylase HemK
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01170
PF03602
PF05175
PF06325
PF08241

PRINTS

PR00506

PIRSF

PIRSF015855
PIRSF004553

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt