InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LTB

Summary

InnateDB Protein

IDBP-371563.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTB

Protein Name

lymphotoxin beta (TNF superfamily, member 3)

Synonyms

p33; TNFC; TNFSF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000410481

InnateDB Gene

IDBG-302504 (LTB)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Spleen and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0010467	gene expression
GO:0043588	skin development
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0048535	lymph node development