InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYD88

Summary

InnateDB Protein

IDBP-371938.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYD88

Protein Name

myeloid differentiation primary response gene (88)

Synonyms

MYD88D;

Species

Homo sapiens

Ensembl Protein

ENSP00000401399

InnateDB Gene

IDBG-25713 (MYD88)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	120 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005121	Toll binding
GO:0005123	death receptor binding
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0070976	TIR domain binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002238	response to molecule of fungal origin
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007254	JNK cascade
GO:0008063	Toll signaling pathway
GO:0009615	response to virus
GO:0016064	immunoglobulin mediated immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032481	positive regulation of type I interferon production
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032740	positive regulation of interleukin-17 production
GO:0032747	positive regulation of interleukin-23 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130	negative regulation of growth of symbiont in host
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0046330	positive regulation of JNK cascade
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050727	regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070555	response to interleukin-1
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:0071260	cellular response to mechanical stimulus
GO:0090557	establishment of endothelial intestinal barrier

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0014069	postsynaptic density
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000488 Death domain
IPR011029 Death-like domain
IPR017281 Myeloid differentiation primary response protein MyD88

PFAM

PF01582
PF13676
PF00531

PRINTS

PIRSF

PIRSF037756

SMART

SM00255
SM00005

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt