Version 5.4
Homo sapiens Protein: SERPINB2
Summary
InnateDB Protein IDBP-372020.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB2
Protein Name serpin peptidase inhibitor, clade B (ovalbumin), member 2
Synonyms HsT1201; PAI; PAI-2; PAI2; PLANH2;
Species Homo sapiens
Ensembl Protein ENSP00000401645
InnateDB Gene IDBG-4558 (SERPINB2)
Protein Structure
UniProt Annotation
Function Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.
Subcellular Localization Cytoplasm. Secreted, extracellular space.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0042060 wound healing
GO:0042730 fibrinolysis
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05120
PhosphoSite PhosphoSite-P05120
TrEMBL Q6LDR6
UniProt Splice Variant
Entrez Gene 5055
UniGene Hs.644669
RefSeq NP_001137290
HUGO HGNC:8584
OMIM 173390
CCDS CCDS11989
HPRD 01420
IMGT
EMBL AC072051 BC012609 J02685 J03603 M18082 M23092 M24651 M24652 M24653 M24654 M24655 M24656 M24657 M31547 M31548 M31549 M31550 M31551 Y00630
GenPept AAA36413 AAA36797 AAA60004 AAA60005 AAA60006 AAA60348 AAH12609 CAA68666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca