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InnateDB Protein
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IDBP-372234.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIP5K1B
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Protein Name
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phosphatidylinositol-4-phosphate 5-kinase, type I, beta
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Synonyms
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MSS4; STM7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398587
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InnateDB Gene
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IDBG-69048 (PIP5K1B)
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Protein Structure
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| Function |
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. {ECO:0000269PubMed:8955136}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
3
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
3 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0016307
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phosphatidylinositol phosphate kinase activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR002498
Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034
Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
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| PFAM |
PF01504
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| PRINTS |
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| PIRSF |
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| SMART |
SM00330
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-O14986
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
8395
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| UniGene |
Hs.534371
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| RefSeq |
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| HUGO |
HGNC:8995
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| OMIM |
602745
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| CCDS |
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| HPRD |
04121
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4