InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCN5A

Summary

InnateDB Protein

IDBP-372406.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN5A

Protein Name

sodium channel, voltage-gated, type V, alpha subunit

Synonyms

CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000388797

InnateDB Gene

IDBG-26059 (SCN5A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001696 Voltage gated sodium channel, alpha subunit
IPR005821 Ion transport domain
IPR008053 Voltage gated sodium channel, alpha-5 subunit
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR024583 Domain of unknown function DUF3451

PFAM

PF00520
PF06512
PF08016
PF11933

PRINTS

PR00170
PR01666

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite