Homo sapiens Protein: ALDH3A1
Summary
InnateDB Protein IDBP-372696.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH3A1
Protein Name aldehyde dehydrogenase 3 family, member A1
Synonyms ALDH3; ALDHIII;
Species Homo sapiens
Ensembl Protein ENSP00000411821
InnateDB Gene IDBG-35000 (ALDH3A1)
Protein Structure
UniProt Annotation
Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity High levels in stomach, esophagus and lung; low level in the liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0001666 response to hypoxia
GO:0006081 cellular aldehyde metabolic process
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0008218 bioluminescence
GO:0008284 positive regulation of cell proliferation
GO:0014070 response to organic cyclic compound
GO:0042493 response to drug
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR008670 Acyl-CoA reductase, LuxC
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase
PFAM PF05893
PF00171
PRINTS
PIRSF PIRSF009414
PIRSF036492
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30838
PhosphoSite PhosphoSite-P30838
TrEMBL I3L4E5
UniProt Splice Variant
Entrez Gene 218
UniGene Hs.531682
RefSeq NP_001128640
HUGO HGNC:405
OMIM 100660
CCDS CCDS11212
HPRD 00004
IMGT
EMBL AC005722 AK292193 AK314584 BC004370 BC008892 BC021194 BT007102 CH471212 M74542 M77477 S61044
GenPept AAA51696 AAB26658 AAB46377 AAH04370 AAH08892 AAH21194 AAP35766 BAF84882 BAG37160 EAW50909