Version 5.4
Homo sapiens Protein: DOCK9
Summary
InnateDB Protein IDBP-372719.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK9
Protein Name dedicator of cytokinesis 9
Synonyms ZIZ1; ZIZIMIN1;
Species Homo sapiens
Ensembl Protein ENSP00000403528
InnateDB Gene IDBG-45550 (DOCK9)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269PubMed:12172552, ECO:0000269PubMed:19745154}.
Subcellular Localization Endomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. {ECO:0000269PubMed:12172552}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9BZ29
TrEMBL X6RGR3
UniProt Splice Variant
Entrez Gene 23348
UniGene Hs.596105
RefSeq
HUGO HGNC:14132
OMIM 607325
CCDS
HPRD 09542
IMGT
EMBL AL139084 AL161420 AL391122
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca