InnateDB Protein
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IDBP-373007.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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E2F5
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Protein Name
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E2F transcription factor 5, p130-binding
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Synonyms
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E2F-5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414312
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InnateDB Gene
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IDBG-27065 (E2F5)
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Protein Structure
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Function |
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
|
Protein-Protein |
11
[view]
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Protein-DNA |
10
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000278
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mitotic cell cycle
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0010467
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gene expression
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051726
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regulation of cell cycle
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Cellular Component |
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PDB ID |
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InterPro |
IPR003316
Transcription factor E2F/dimerisation partner (TDP)
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PFAM |
PF02319
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15329
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PhosphoSite |
PhosphoSite-Q15329
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1875
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UniGene |
Hs.445758
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RefSeq |
NP_001077057
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HUGO |
HGNC:3119
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OMIM |
600967
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CCDS |
CCDS47886
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HPRD |
02983
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IMGT |
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EMBL |
AC011773
AL583354
AY162833
U15642
U31556
X86097
Z78409
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GenPept |
AAB00179
AAC50120
AAN46737
CAA60051
CAB01634
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