InnateDB Protein
|
IDBP-373150.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SLC38A4
|
Protein Name
|
solute carrier family 38, member 4
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000389843
|
InnateDB Gene
|
IDBG-28651 (SLC38A4)
|
Protein Structure
|
|
Function |
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269PubMed:11342143, ECO:0000269PubMed:11414754}.
|
Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11414754, ECO:0000269PubMed:16148032}; Multi-pass membrane protein {ECO:0000269PubMed:11414754, ECO:0000269PubMed:16148032}.
|
Disease Associations |
|
Tissue Specificity |
Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. {ECO:0000269PubMed:11342143, ECO:0000269PubMed:11414754, ECO:0000269PubMed:16148032}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0015171
|
amino acid transmembrane transporter activity
|
GO:0015293
|
symporter activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR013057
Amino acid transporter, transmembrane
|
PFAM |
PF01490
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q969I6
|
PhosphoSite |
PhosphoSite-Q969I6
|
TrEMBL |
F8VRD9
|
UniProt Splice Variant |
|
Entrez Gene |
55089
|
UniGene |
Hs.694012
|
RefSeq |
NP_001137296
|
HUGO |
HGNC:14679
|
OMIM |
608065
|
CCDS |
CCDS8750
|
HPRD |
12159
|
IMGT |
|
EMBL |
AB055003
AC008014
AC080136
AF193836
AF305814
AK291168
BC069819
BC101827
BC104913
CH471111
|
GenPept |
AAH69819
AAI01828
AAI04914
AAK43528
AAK71508
BAB84090
BAF83857
EAW57919
EAW57920
|
|
|