InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCC

Summary

InnateDB Protein

IDBP-37349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCC

Protein Name

mutated in colorectal cancers

Synonyms

MCC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000305617

InnateDB Gene

IDBG-37345 (MCC)

Protein Structure

UniProt Annotation

Function

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. {ECO:0000269PubMed:18591935, ECO:0000269PubMed:19555689, ECO:0000269PubMed:22480440}.

Subcellular Localization

Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0010633	negative regulation of epithelial cell migration
GO:0016055	Wnt signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0090090	negative regulation of canonical Wnt signaling pathway