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InnateDB Protein
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IDBP-374103.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FAM21C
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Protein Name
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family with sequence similarity 21, member C
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000416630
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InnateDB Gene
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IDBG-72147 (FAM21C)
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Protein Structure
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| Function |
Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells. {ECO:0000269PubMed:18550675, ECO:0000269PubMed:19922874}.
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| Subcellular Localization |
Early endosome membrane. Cell membrane. Note=Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
18
[view]
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| Protein-Protein |
18
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9Y4E1
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
387680
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| UniGene |
Hs.602222
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| RefSeq |
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| HUGO |
HGNC:23414
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| OMIM |
613631
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| CCDS |
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| HPRD |
11094
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4