Version 5.4
Homo sapiens Protein: ZDHHC3
Summary
InnateDB Protein IDBP-374225.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZDHHC3
Protein Name zinc finger, DHHC-type containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000395502
InnateDB Gene IDBG-29370 (ZDHHC3)
Protein Structure
UniProt Annotation
Function Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0018345 protein palmitoylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
PFAM PF01529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYG2
PhosphoSite PhosphoSite-Q9NYG2
TrEMBL C9JNU5
UniProt Splice Variant
Entrez Gene 51304
UniGene Hs.61430
RefSeq NP_001128651
HUGO HGNC:18470
OMIM
CCDS CCDS46811
HPRD 15718
IMGT
EMBL AC098649 AC104165 AF247703 AF441791 AY605661 BC015467
GenPept AAF63570 AAH15467 AAL34547 AAV83779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca