InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO43

Summary

InnateDB Protein

IDBP-374398.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO43

Protein Name

F-box protein 43

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000403293

InnateDB Gene

IDBG-30514 (FBXO43)

Protein Structure

UniProt Annotation

Function

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). {ECO:0000305}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007126	meiotic nuclear division
GO:0016567	protein ubiquitination
GO:0040020	regulation of meiosis
GO:0042177	negative regulation of protein catabolic process
GO:0045835	negative regulation of meiosis