Version 5.4
Homo sapiens Protein: CASP14
Summary
InnateDB Protein IDBP-374473.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP14
Protein Name caspase 14, apoptosis-related cysteine peptidase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393417
InnateDB Gene IDBG-34154 (CASP14)
Protein Structure
UniProt Annotation
Function Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. {ECO:0000269PubMed:11175259}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0008544 epidermis development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0031424 keratinization
GO:0070268 cornification
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
PFAM PF00656
PRINTS PR00376
PIRSF
SMART SM00115
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31944
PhosphoSite PhosphoSite-
TrEMBL B2CIS9
UniProt Splice Variant
Entrez Gene 23581
UniGene Hs.466057
RefSeq NP_036246
HUGO HGNC:1502
OMIM 605848
CCDS CCDS12323
HPRD 05788
IMGT
EMBL AF097874 AK313992 BC069541 BC103868 BC103869 CH471106 EU502748
GenPept AAD16173 AAH69541 AAI03869 AAI03870 ACA63845 BAG36704 EAW84459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca