InnateDB Protein
|
IDBP-374528.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
YWHAZ
|
Protein Name
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
|
Synonyms
|
14-3-3-zeta; HEL-S-3; HEL4; KCIP-1; YWHAD;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000395114
|
InnateDB Gene
|
IDBG-30919 (YWHAZ)
|
Protein Structure
|
|
Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. {ECO:0000269PubMed:14578935, ECO:0000269PubMed:15071501, ECO:0000269PubMed:15644438, ECO:0000269PubMed:16376338, ECO:0000269PubMed:9360956}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Located to stage I to stage IV melanosomes.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 769 experimentally validated interaction(s) in this database.
They are also associated with 155 interaction(s) predicted by orthology.
Experimentally validated |
Total |
769
[view]
|
Protein-Protein |
767
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
155 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000308
14-3-3 protein
IPR023410
14-3-3 domain
|
PFAM |
PF00244
|
PRINTS |
PR00305
|
PIRSF |
PIRSF000868
|
SMART |
SM00101
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P63104
|
PhosphoSite |
PhosphoSite-P63104
|
TrEMBL |
Q6LD62
|
UniProt Splice Variant |
|
Entrez Gene |
7534
|
UniGene |
Hs.593532
|
RefSeq |
|
HUGO |
HGNC:12855
|
OMIM |
601288
|
CCDS |
CCDS6290
|
HPRD |
03183
|
IMGT |
|
EMBL |
AC018781
AC027373
AK289945
AK294647
AK296902
AK315867
BC003623
BC051814
BC063824
BC068456
BC072426
BC073141
BC083508
BC099904
BC101483
BC108281
BC111951
CH471060
DQ185048
EF094937
EU794582
EU794583
M86400
S79449
U28964
|
GenPept |
AAA36446
AAC52052
AAD14300
AAH03623
AAH51814
AAH63824
AAH68456
AAH72426
AAH73141
AAH83508
AAH99904
AAI01484
AAI08282
AAI11952
ABD14427
ABO15003
ACJ13636
ACJ13637
BAF82634
BAF98758
BAH11832
BAH12451
EAW91823
EAW91824
EAW91825
EAW91826
EAW91827
EAW91828
EAW91829
|
|
|