Version 5.4
Homo sapiens Protein: MSH2
Summary
InnateDB Protein IDBP-374902.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSH2
Protein Name mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Synonyms COCA1; FCC1; HNPCC; HNPCC1; LCFS2;
Species Homo sapiens
Ensembl Protein ENSP00000411482
InnateDB Gene IDBG-50900 (MSH2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 132 [view]
Protein-Protein 132 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
Biological Process
GO:0006298 mismatch repair
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR007860 DNA mismatch repair protein MutS, connector domain
PFAM PF01624
PF05188
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL C9J809
UniProt Splice Variant
Entrez Gene 4436
UniGene Hs.597656
RefSeq
HUGO HGNC:7325
OMIM 609309
CCDS
HPRD 00389
IMGT
EMBL AC079775 AC138655
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca