InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRXN3

Summary

InnateDB Protein

IDBP-375038.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN3

Protein Name

neurexin 3

Synonyms

C14orf60;

Species

Homo sapiens

Ensembl Protein

ENSP00000394426

InnateDB Gene

IDBG-14238 (NRXN3)

Protein Structure

UniProt Annotation

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the blood vessel walls (at protein level). {ECO:0000269PubMed:19926856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0001525	angiogenesis
GO:0007158	neuron cell-cell adhesion
GO:0007269	neurotransmitter secretion
GO:0007416	synapse assembly
GO:0007612	learning
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0051965	positive regulation of synapse assembly
GO:0071625	vocalization behavior
GO:0090129	positive regulation of synapse maturation