Homo sapiens Protein: ACVR1B | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-375358.5 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | ACVR1B | ||||||||||||||||||||||||||||||||||
Protein Name | activin A receptor, type IB | ||||||||||||||||||||||||||||||||||
Synonyms | ACTRIB; ACVRLK4; ALK4; SKR2; | ||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000390477 | ||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-33695 (ACVR1B) | ||||||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||||||
Function | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. {ECO:0000269PubMed:12364468, ECO:0000269PubMed:12639945, ECO:0000269PubMed:18039968, ECO:0000269PubMed:20226172, ECO:0000269PubMed:8196624, ECO:0000269PubMed:9032295, ECO:0000269PubMed:9892009}. | ||||||||||||||||||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | ||||||||||||||||||||||||||||||||||
Disease Associations | Note=ACVRIB is abundantly expressed in systemic sclerosis patient fibroblasts and production of collagen is also induced by activin-A/INHBA. This suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. | ||||||||||||||||||||||||||||||||||
Tissue Specificity | Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. | ||||||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||||||
InterPro |
IPR000472
TGF-beta receptor/activin receptor, type I/II IPR000719 Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR003605 TGF beta receptor, GS motif IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF01064
PF00069 PF07714 PF08515 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||||||||||||||
SMART |
SM00220
SM00467 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | P36896 | ||||||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P36896 | ||||||||||||||||||||||||||||||||||
TrEMBL | F5H5Q2 | ||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | 91 | ||||||||||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||||||||||
HUGO | HGNC:172 | ||||||||||||||||||||||||||||||||||
OMIM | 601300 | ||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||
HPRD | 03193 | ||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | AC025259 AK299120 AK299496 BC000254 BC040531 BT007072 L10125 L10126 L31848 U14722 Z22536 | ||||||||||||||||||||||||||||||||||
GenPept | AAA50246 AAA53349 AAA53350 AAA53351 AAA60555 AAA60556 AAH00254 AAH40531 AAP35735 BAH12954 BAH13051 CAA80258 | ||||||||||||||||||||||||||||||||||