InnateDB Protein
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IDBP-375722.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C9orf3
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Protein Name
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chromosome 9 open reading frame 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387736
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InnateDB Gene
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IDBG-76959 (C9orf3)
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Protein Structure
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Function |
Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. {ECO:0000269PubMed:15687497}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney. {ECO:0000269PubMed:15687497}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q8N6M6
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TrEMBL |
X6RBX4
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UniProt Splice Variant |
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Entrez Gene |
84909
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UniGene |
Hs.680988
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RefSeq |
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HUGO |
HGNC:1361
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OMIM |
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CCDS |
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HPRD |
07476
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IMGT |
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EMBL |
AL157936
AL353768
AL354893
AL807757
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GenPept |
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