InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C9orf3

Summary

InnateDB Protein

IDBP-375732.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C9orf3

Protein Name

chromosome 9 open reading frame 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000401854

InnateDB Gene

IDBG-76959 (C9orf3)

Protein Structure

UniProt Annotation

Function

Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. {ECO:0000269PubMed:15687497}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney. {ECO:0000269PubMed:15687497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0019370

leukotriene biosynthetic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold

PFAM

PF01433
PF09127

PRINTS

PR00756

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite