InnateDB Protein
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IDBP-376006.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZWILCH
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Protein Name
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Zwilch, kinetochore associated, homolog (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402217
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InnateDB Gene
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IDBG-18211 (ZWILCH)
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Protein Structure
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Function |
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. {ECO:0000269PubMed:15824131}.
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Subcellular Localization |
Chromosome, centromere, kinetochore {ECO:0000269PubMed:20462495}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018630
RZZ complex, subunit zwilch
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PFAM |
PF09817
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H900
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PhosphoSite |
PhosphoSite-Q9H900
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TrEMBL |
H3BSG1
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UniProt Splice Variant |
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Entrez Gene |
55055
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UniGene |
Hs.585062
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RefSeq |
NP_001274752
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HUGO |
HGNC:25468
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OMIM |
609984
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CCDS |
CCDS73746
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HPRD |
07640
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IMGT |
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EMBL |
AC116913
AK000898
AK023175
AK027468
AK122787
BC036900
BC090041
BX640701
CH471082
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GenPept |
AAH36900
AAH90041
BAB14446
BAB55133
BAG53730
CAE45821
EAW77779
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