Version 5.4
Homo sapiens Protein: ATRIP
Summary
InnateDB Protein IDBP-376008.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATRIP
Protein Name ATR interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400930
InnateDB Gene IDBG-32700 (ATRIP)
Protein Structure
UniProt Annotation
Function Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269PubMed:12791985}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11721054, ECO:0000269PubMed:18283122}. Note=Redistributes to discrete nuclear foci upon DNA damage.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:11721054}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXE1
PhosphoSite PhosphoSite-Q8WXE1
TrEMBL C9IZM8
UniProt Splice Variant
Entrez Gene 84126
UniGene Hs.694840
RefSeq NP_001257952
HUGO HGNC:33499
OMIM 606609
CCDS CCDS59449
HPRD
IMGT
EMBL AC104448 AF451323 AK022405 AK291568 AK291829 AK300548 AK315075 AL832917 BC014153 BC020563 BC030597 CH471055
GenPept AAH14153 AAH20563 AAH30597 AAL38042 BAB14029 BAF84257 BAF84518 BAG37544 BAG62254 CAH10621 EAW64876 EAW64878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca