Version 5.4
Homo sapiens Protein: IRF1
Summary
InnateDB Protein IDBP-376299.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF1
Protein Name interferon regulatory factor 1
Synonyms IRF-1; MAR;
Species Homo sapiens
Ensembl Protein ENSP00000405655
InnateDB Gene IDBG-42125 (IRF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 206 [view]
Protein-Protein 70 [view]
Protein-DNA 135 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
PFAM PF00605
PRINTS PR00267
PIRSF
SMART SM00348
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL X5D3F6
UniProt Splice Variant
Entrez Gene 3659
UniGene Hs.672951
RefSeq
HUGO HGNC:6116
OMIM 147575
CCDS
HPRD 00961
IMGT
EMBL AC116366 KJ200634
GenPept AHW49378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca