InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LASP1

Summary

InnateDB Protein

IDBP-376873.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LASP1

Protein Name

LIM and SH3 protein 1

Synonyms

Lasp-1; MLN50;

Species

Homo sapiens

Ensembl Protein

ENSP00000392853

InnateDB Gene

IDBG-45070 (LASP1)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the F- actin rich cortical cytoskeleton. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015075	ion transmembrane transporter activity