Version 5.4
Homo sapiens Protein: LASP1
Summary
InnateDB Protein IDBP-376875.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LASP1
Protein Name LIM and SH3 protein 1
Synonyms Lasp-1; MLN50;
Species Homo sapiens
Ensembl Protein ENSP00000401048
InnateDB Gene IDBG-45070 (LASP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015075 ion transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000900 Nebulin repeat
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00880
PF00018
PF14604
PF07653
PRINTS PR00452
PIRSF
SMART SM00227
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14847
PhosphoSite PhosphoSite-Q14847
TrEMBL
UniProt Splice Variant
Entrez Gene 3927
UniGene Hs.741156
RefSeq NP_001258537
HUGO HGNC:6513
OMIM 602920
CCDS CCDS62164
HPRD 04229
IMGT
EMBL AC006441 AC110749 AK294704 BC007560 BC012460 X82456
GenPept AAH07560 AAH12460 BAG57861 CAA57833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca