InnateDB Protein
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IDBP-377095.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VEGFB
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Protein Name
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vascular endothelial growth factor B
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Synonyms
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VEGFL; VRF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000401550
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InnateDB Gene
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IDBG-53284 (VEGFB)
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Protein Structure
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Function |
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
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Subcellular Localization |
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001938
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positive regulation of endothelial cell proliferation
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GO:0002576
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platelet degranulation
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GO:0007596
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blood coagulation
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GO:0010629
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negative regulation of gene expression
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GO:0030168
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platelet activation
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GO:0030949
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positive regulation of vascular endothelial growth factor receptor signaling pathway
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GO:0035470
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positive regulation of vascular wound healing
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GO:0043066
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negative regulation of apoptotic process
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0048010
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vascular endothelial growth factor receptor signaling pathway
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0050918
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positive chemotaxis
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GO:0050930
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induction of positive chemotaxis
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GO:0051781
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positive regulation of cell division
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GO:0051897
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positive regulation of protein kinase B signaling
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GO:0060754
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positive regulation of mast cell chemotaxis
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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Cellular Component |
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PDB ID |
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InterPro |
IPR000072
PDGF/VEGF domain
IPR027928
Vascular endothelial growth factor, heparin-binding domain
IPR029034
Cystine-knot cytokine
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PFAM |
PF00341
PF14554
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PRINTS |
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PIRSF |
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SMART |
SM00141
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TIGRFAMs |
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Modification |
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SwissProt |
P49765
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7423
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UniGene |
Hs.78781
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RefSeq |
NP_001230662
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HUGO |
HGNC:12681
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OMIM |
601398
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CCDS |
CCDS58144
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HPRD |
03237
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IMGT |
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EMBL |
BC008818
U43368
U43369
U48801
U52819
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GenPept |
AAA91462
AAA91463
AAB06274
AAC50721
AAH08818
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