InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPX1

Summary

InnateDB Protein

IDBP-377186.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPX1

Protein Name

glutathione peroxidase 1

Synonyms

GPXD; GSHPX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000391316

InnateDB Gene

IDBG-305033 (GPX1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006749	glutathione metabolic process
GO:0006979	response to oxidative stress
GO:0009650	UV protection
GO:0010269	response to selenium ion
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0033599	regulation of mammary gland epithelial cell proliferation
GO:0040029	regulation of gene expression, epigenetic
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044281	small molecule metabolic process
GO:0045454	cell redox homeostasis
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0061136	regulation of proteasomal protein catabolic process
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors