InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERBB2

Summary

InnateDB Protein

IDBP-377207.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERBB2

Protein Name

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Synonyms

CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000404047

InnateDB Gene

IDBG-46068 (ERBB2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	209 [view]
Protein-Protein	199 [view]
Protein-DNA	7 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000494 EGF receptor, L domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01030
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00261
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt