InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMT

Summary

InnateDB Protein

IDBP-377235.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMT

Protein Name

aminomethyltransferase

Synonyms

GCE; GCST; GCVT; NKH;

Species

Homo sapiens

Ensembl Protein

ENSP00000415619

InnateDB Gene

IDBG-34823 (AMT)

Protein Structure

UniProt Annotation

Function

The glycine cleavage system catalyzes the degradation of glycine.

Subcellular Localization

Mitochondrion.

Disease Associations

Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. {ECO:0000269PubMed:10873393, ECO:0000269PubMed:11286506, ECO:0000269PubMed:8005589, ECO:0000269PubMed:9600239, ECO:0000269PubMed:9621520}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004047	aminomethyltransferase activity
GO:0008483	transaminase activity

Biological Process

GO:0006546	glycine catabolic process
GO:0032259	methylation

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR006222 Glycine cleavage T-protein, N-terminal
IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
IPR028896 Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA
IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain

PFAM

PF01571
PF08669

PRINTS

PIRSF

PIRSF006487

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48728