Version 5.4
Homo sapiens Protein: CD63
Summary
InnateDB Protein IDBP-377287.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD63
Protein Name CD63 molecule
Synonyms LAMP-3; ME491; MLA1; OMA81H; TSPAN30;
Species Homo sapiens
Ensembl Protein ENSP00000393502
InnateDB Gene IDBG-38974 (CD63)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0002576 platelet degranulation
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0034613 cellular protein localization
GO:0035646 endosome to melanosome transport
GO:0045087 innate immune response (InnateDB)
GO:0048757 pigment granule maturation
GO:1900746 regulation of vascular endothelial growth factor signaling pathway
GO:2000680 regulation of rubidium ion transport
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031088 platelet dense granule membrane
GO:0031226 intrinsic component of plasma membrane
GO:0031902 late endosome membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0097487 multivesicular body, internal vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F8W022
UniProt Splice Variant
Entrez Gene 967
UniGene Hs.613137
RefSeq NP_001244319
HUGO HGNC:1692
OMIM 155740
CCDS CCDS8890
HPRD 01121
IMGT
EMBL AC009779 AF508304 AK311893 BC002349 BC013017 BT007073 BT020137 BT020138 CH471054 CR542096 M58485 M59907 S93788 X07982 X62654
GenPept AAA63235 AAB21617 AAH02349 AAH13017 AAM34259 AAP35736 AAV38939 AAV38940 BAG34834 CAA30792 CAA44519 CAG46893 EAW96827 EAW96828 EAW96829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca