Version 5.4
Homo sapiens Protein: CLGN
Summary
InnateDB Protein IDBP-377919.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLGN
Protein Name calmegin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392782
InnateDB Gene IDBG-38740 (CLGN)
Protein Structure
UniProt Annotation
Function Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Detected in testis (at protein level). Detected in testis. {ECO:0000269PubMed:9434179}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007338 single fertilization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001580 Calreticulin/calnexin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009033 Calreticulin/calnexin, P domain
PFAM PF00262
PRINTS PR00626
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14967
PhosphoSite PhosphoSite-O14967
TrEMBL D6RAZ4
UniProt Splice Variant
Entrez Gene 1047
UniGene Hs.86368
RefSeq NP_001124147
HUGO HGNC:2060
OMIM 601858
CCDS CCDS3751
HPRD 03513
IMGT
EMBL AC093671 AK093096 AK299243 BC028357 CH471056 D86322
GenPept AAH28357 BAA22590 BAG52652 BAG61274 EAX05099 EAX05100 EAX05101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca