InnateDB Protein
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IDBP-37818.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COPZ1
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Protein Name
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coatomer protein complex, subunit zeta 1
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Synonyms
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COPZ; HSPC181; zeta-COP; zeta1-COP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262061
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InnateDB Gene
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IDBG-37816 (COPZ1)
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Protein Structure
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Function |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011012
Longin-like domain
IPR022775
AP complex, mu/sigma subunit
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PFAM |
PF01217
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61923
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PhosphoSite |
PhosphoSite-P61923
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TrEMBL |
F8VYZ4
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UniProt Splice Variant |
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Entrez Gene |
22818
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UniGene |
Hs.505652
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RefSeq |
NP_057141
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HUGO |
HGNC:2243
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OMIM |
615472
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CCDS |
CCDS8877
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HPRD |
16738
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IMGT |
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EMBL |
AB047848
AC078778
AF086911
AF151878
AF161529
AK293377
AK295325
BC002849
CH471054
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GenPept |
AAD34115
AAF29144
AAH02849
AAP97141
BAB17659
BAG56889
BAG58302
EAW96774
EAW96775
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