InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAT6

Summary

InnateDB Protein

IDBP-378397.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT6

Protein Name

signal transducer and activator of transcription 6, interleukin-4 induced

Synonyms

D12S1644; IL-4-STAT; STAT6B; STAT6C;

Species

Homo sapiens

Ensembl Protein

ENSP00000401486

InnateDB Gene

IDBG-42122 (STAT6)

Protein Structure

UniProt Annotation

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269PubMed:17210636}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	79 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0032481	positive regulation of type I interferon production
GO:0035771	interleukin-4-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt