Version 5.4
Homo sapiens Protein: PCYOX1
Summary
InnateDB Protein IDBP-378590.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCYOX1
Protein Name prenylcysteine oxidase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387654
InnateDB Gene IDBG-55265 (PCYOX1)
Protein Structure
UniProt Annotation
Function Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001735 prenylcysteine oxidase activity
GO:0008555 chloride-transporting ATPase activity
GO:0016491 oxidoreductase activity
GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
Biological Process
GO:0006821 chloride transport
GO:0030327 prenylated protein catabolic process
GO:0030328 prenylcysteine catabolic process
GO:0030329 prenylcysteine metabolic process
GO:0055114 oxidation-reduction process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0034361 very-low-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002937 Amine oxidase
IPR006076 FAD dependent oxidoreductase
IPR010795 Prenylcysteine lyase
IPR017046 Prenylcysteine oxidase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
PFAM PF01593
PF01266
PF07156
PF07992
PRINTS
PIRSF PIRSF036292
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHG3
PhosphoSite PhosphoSite-Q9UHG3
TrEMBL Q584P1
UniProt Splice Variant
Entrez Gene 51449
UniGene Hs.639218
RefSeq NP_057381
HUGO HGNC:20588
OMIM 610995
CCDS CCDS1902
HPRD 11422
IMGT
EMBL AB020715 AC016700 AC079338 AF181490 AK296478 AK303043 AK314453 AK316013 AY359063 BC007029 BC033815 BC051891 CH471053
GenPept AAF16937 AAH07029 AAH33815 AAH51891 AAQ89422 AAX81995 AAX93194 BAA74931 BAG37061 BAH12368 BAH13888 BAH14384 EAW99819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca