InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFA

Summary

InnateDB Protein

IDBP-378654.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFA

Protein Name

transforming growth factor, alpha

Synonyms

TFGA;

Species

Homo sapiens

Ensembl Protein

ENSP00000387493

InnateDB Gene

IDBG-55377 (TGFA)

Protein Structure

UniProt Annotation

Function

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Subcellular Localization

Transforming growth factor alpha: Secreted, extracellular space.Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. {ECO:0000269PubMed:10523832}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004708	MAP kinase kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0008283	cell proliferation
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051781	positive regulation of cell division

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0048471	perinuclear region of cytoplasm