InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MID2

Summary

InnateDB Protein

IDBP-378870.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MID2

Protein Name

midline 2

Synonyms

FXY2; MRX101; RNF60; TRIM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000413976

InnateDB Gene

IDBG-81697 (MID2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.

Disease Associations

Tissue Specificity

Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0035372	protein localization to microtubule
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003649 B-box, C-terminal
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM