InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPO11

Summary

InnateDB Protein

IDBP-379176.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPO11

Protein Name

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

Synonyms

CT35; SPATA43; TOPVIA;

Species

Homo sapiens

Ensembl Protein

ENSP00000413185

InnateDB Gene

IDBG-82085 (SPO11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006259	DNA metabolic process
GO:0007131	reciprocal meiotic recombination

Cellular Component

GO:0005694

chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR002815 Spo11/DNA topoisomerase VI subunit A
IPR004084 Meiosis-specific protein Spo11
IPR013048 Meiotic recombination, Spo11
IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminal

PFAM

PF03533
PF04406

PRINTS

PR01550
PR01551

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5TCH6

UniProt Splice Variant

Entrez Gene

23626

UniGene

Hs.159737

RefSeq

HUGO

HGNC:11250

OMIM

605114

CCDS

HPRD

09236

IMGT

EMBL

AL135939

GenPept