InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF1

Summary

InnateDB Protein

IDBP-379194.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF1

Protein Name

fibroblast growth factor 1 (acidic)

Synonyms

AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000396195

InnateDB Gene

IDBG-51235 (FGF1)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269PubMed:16597617, ECO:0000269PubMed:20145243, ECO:0000269PubMed:8663044}.

Subcellular Localization

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. {ECO:0000269PubMed:11964394, ECO:0000269PubMed:7504343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0044548	S100 protein binding

Biological Process

GO:0001525	angiogenesis
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009653	anatomical structure morphogenesis
GO:0030335	positive regulation of cell migration
GO:0034605	cellular response to heat
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051781	positive regulation of cell division
GO:0060681	branch elongation involved in ureteric bud branching
GO:0072163	mesonephric epithelium development
GO:1902533	positive regulation of intracellular signal transduction