InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEZ6

Summary

InnateDB Protein

IDBP-37927.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEZ6

Protein Name

seizure related 6 homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000312942

InnateDB Gene

IDBG-37925 (SEZ6)

Protein Structure

UniProt Annotation

Function

May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized on dendrites and in the synaptic and postsynaptic fraction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0008344	adult locomotory behavior
GO:0021680	cerebellar Purkinje cell layer development
GO:0050773	regulation of dendrite development
GO:0060074	synapse maturation
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0090036	regulation of protein kinase C signaling
GO:1900006	positive regulation of dendrite development
GO:2000171	negative regulation of dendrite development

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0048471	perinuclear region of cytoplasm
GO:0097440	apical dendrite