InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARD6A

Summary

InnateDB Protein

IDBP-379297.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARD6A

Protein Name

par-6 partitioning defective 6 homolog alpha (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000392388

InnateDB Gene

IDBG-37154 (PARD6A)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269PubMed:10873802}.

Subcellular Localization

Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

Disease Associations

Tissue Specificity

Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017048	Rho GTPase binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016032	viral process
GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0045217	cell-cell junction maintenance
GO:0051301	cell division
GO:0070830	tight junction assembly