InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NBR1

Summary

InnateDB Protein

IDBP-379319.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NBR1

Protein Name

neighbor of BRCA1 gene 1

Synonyms

1A1-3B; IAI3B; M17S2;

Species

Homo sapiens

Ensembl Protein

ENSP00000411250

InnateDB Gene

IDBG-52662 (NBR1)

Protein Structure

UniProt Annotation

Function

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. {ECO:0000269PubMed:19250911}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	200 [view]
Protein-Protein	192 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043130	ubiquitin binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0016236	macroautophagy
GO:0030500	regulation of bone mineralization
GO:0032872	regulation of stress-activated MAPK cascade
GO:0045668	negative regulation of osteoblast differentiation
GO:0051259	protein oligomerization

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0016020	membrane
GO:0031410	cytoplasmic vesicle
GO:0031430	M band
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR000433 Zinc finger, ZZ-type
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

PFAM

PF00564
PF00569

PRINTS

PIRSF

SMART

SM00666
SM00291
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14596