InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOMER2

Summary

InnateDB Protein

IDBP-379367.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOMER2

Protein Name

homer homolog 2 (Drosophila)

Synonyms

ACPD; CPD; HOMER-2; VESL-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000407634

InnateDB Gene

IDBG-26846 (HOMER2)

Protein Structure

UniProt Annotation

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

Subcellular Localization

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007216

G-protein coupled glutamate receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045211	postsynaptic membrane