Version 5.4
Homo sapiens Protein: SH3GL3
Summary
InnateDB Protein IDBP-379417.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3GL3
Protein Name SH3-domain GRB2-like 3
Synonyms CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13;
Species Homo sapiens
Ensembl Protein ENSP00000391372
InnateDB Gene IDBG-27199 (SH3GL3)
Protein Structure
UniProt Annotation
Function Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Brain and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007417 central nervous system development
Cellular Component
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF03114
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99963
PhosphoSite PhosphoSite-Q99963
TrEMBL Q9UMB8
UniProt Splice Variant
Entrez Gene 6457
UniGene Hs.599441
RefSeq NP_003018
HUGO HGNC:10832
OMIM 603362
CCDS CCDS10325
HPRD 04528
IMGT
EMBL AF036269 AF036270 AF036271 AF036272 AL109775 CH471188 X99664
GenPept AAC04765 AAC04766 AAC04767 AAC04768 CAA67978 CAB52431 EAW62420 EAW62421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca