InnateDB Protein
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IDBP-37947.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AP3S1
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Protein Name
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adaptor-related protein complex 3, sigma 1 subunit
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Synonyms
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CLAPS3; Sigma3A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000325369
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InnateDB Gene
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IDBG-37945 (AP3S1)
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Protein Structure
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Function |
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
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Subcellular Localization |
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
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Disease Associations |
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Tissue Specificity |
Present in all adult tissues examined. {ECO:0000269PubMed:8697810, ECO:0000269PubMed:9118953, ECO:0000269PubMed:9151686}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011012
Longin-like domain
IPR016635
Adaptor protein complex, sigma subunit
IPR022775
AP complex, mu/sigma subunit
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PFAM |
PF01217
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PRINTS |
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PIRSF |
PIRSF015588
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92572
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PhosphoSite |
PhosphoSite-Q92572
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1176
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UniGene |
Hs.740519
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RefSeq |
NP_001275
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HUGO |
HGNC:2013
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OMIM |
601507
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CCDS |
CCDS4123
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HPRD |
03298
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IMGT |
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EMBL |
BC000804
BT009833
CR450341
D63643
U91932
X99458
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GenPept |
AAD03779
AAH00804
AAP88835
BAA09798
CAA67823
CAG29337
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