Version 5.4
Homo sapiens Protein: CHTF8
Summary
InnateDB Protein IDBP-379692.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHTF8
Protein Name CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408367
InnateDB Gene IDBG-38862 (CHTF8)
Protein Structure
UniProt Annotation
Function Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. {ECO:0000269PubMed:12930902, ECO:0000269PubMed:17545166}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12766176}. Note=Associates with chromatin during S phase.
Disease Associations
Tissue Specificity Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules. {ECO:0000269PubMed:12477976}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006260 DNA replication
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR018607 Chromosome transmission fidelity protein 8
PFAM PF09696
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0CG13
PhosphoSite PhosphoSite-P0CG13
TrEMBL J3KSJ7
UniProt Splice Variant
Entrez Gene 54921
UniGene Hs.85962
RefSeq NP_001034779
HUGO HGNC:24353
OMIM 613202
CCDS CCDS42185
HPRD 16797
IMGT
EMBL AC009027 AF525164 AK000407 BC018700 CH471092
GenPept AAH18700 AAQ08897 BAA91144 EAW83250

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca