Version 5.4
Homo sapiens Protein: AQPEP
Summary
InnateDB Protein IDBP-37996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQPEP
Protein Name Aminopeptidase Q
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350541
InnateDB Gene IDBG-37994 (AQPEP)
Protein Structure
UniProt Annotation
Function Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. {ECO:0000269PubMed:17525158}.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level). {ECO:0000269PubMed:14706636}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
PFAM PF01433
PRINTS PR00756
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6Q4G3
PhosphoSite PhosphoSite-Q6Q4G3
TrEMBL
UniProt Splice Variant
Entrez Gene 206338
UniGene Hs.98288
RefSeq NP_776161
HUGO
OMIM 610046
CCDS CCDS4124
HPRD 07118
IMGT
EMBL AC010282 AC034236 AK075131 AK291655 AY560010 BC036440 BC045809 BC068560 BC070028 BC094716 BC109022 BC109023 CH471086
GenPept AAH68560 AAI09023 AAI09024 AAS66719 BAC11422 BAF84344 EAW48946

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca