Version 5.4
Homo sapiens Protein: IL34
Summary
InnateDB Protein IDBP-380202.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL34
Protein Name interleukin 34
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397863
InnateDB Gene IDBG-40332 (IL34)
Protein Structure
UniProt Annotation
Function Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269PubMed:18467591, ECO:0000269PubMed:20489731, ECO:0000269PubMed:20504948, ECO:0000269PubMed:20829061}.
Subcellular Localization Secreted {ECO:0000269PubMed:18467591}.
Disease Associations
Tissue Specificity Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. {ECO:0000269PubMed:18467591}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006954 inflammatory response
GO:0008284 positive regulation of cell proliferation
GO:0045087 innate immune response
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR020415 Interleukin-34
PFAM PF15036
PRINTS PR01938
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMJ4
PhosphoSite PhosphoSite-
TrEMBL J3QQT3
UniProt Splice Variant
Entrez Gene 146433
UniGene Hs.461214
RefSeq NP_689669
HUGO HGNC:28529
OMIM 612081
CCDS CCDS10895
HPRD 14582
IMGT
EMBL AC020763 AC106804 AK172744 AK314913 BC029804 CH471241 EU599219 EU636994
GenPept AAH29804 ACD13452 ACD13474 BAD18731 BAG37425 EAW51801 EAW51802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca