Version 5.4
Homo sapiens Protein: PPP6C
Summary
InnateDB Protein IDBP-380211.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP6C
Protein Name protein phosphatase 6, catalytic subunit
Synonyms PP6; PP6C;
Species Homo sapiens
Ensembl Protein ENSP00000411744
InnateDB Gene IDBG-85080 (PPP6C)
Protein Structure
UniProt Annotation
Function Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. {ECO:0000269PubMed:10227379, ECO:0000269PubMed:17079228, ECO:0000269PubMed:17568194, ECO:0000269PubMed:9013334}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16769727, ECO:0000269PubMed:17568194}.
Disease Associations
Tissue Specificity Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. {ECO:0000269PubMed:16769727, ECO:0000269PubMed:9013334}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 65 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS PR00114
PIRSF
SMART SM00156
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00743
PhosphoSite PhosphoSite-O00743
TrEMBL B7Z3E2
UniProt Splice Variant
Entrez Gene 5537
UniGene Hs.743623
RefSeq NP_001116841
HUGO HGNC:9323
OMIM 612725
CCDS CCDS48019
HPRD 02141
IMGT
EMBL AF035158 AK295190 AK295752 AK299087 AK312332 AK316527 AL445930 BC006990 BT019708 CH471090 X92972
GenPept AAD45400 AAH06990 AAV38514 BAG35253 BAH12005 BAH12178 BAH12945 BAH14898 CAA63549 CAI13677 EAW87611

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca