InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPP14

Summary

InnateDB Protein

IDBP-380552.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPP14

Protein Name

ribonuclease P/MRP 14kDa subunit

Synonyms

P14;

Species

Homo sapiens

Ensembl Protein

ENSP00000412894

InnateDB Gene

IDBG-42119 (RPP14)

Protein Structure

UniProt Annotation

Function

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004526	ribonuclease P activity
GO:0004540	ribonuclease activity

Biological Process

GO:0008033	tRNA processing
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR002759 Ribonuclease P/MRP protein subunit

PFAM

PF01900

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95059

PhosphoSite

PhosphoSite-O95059

TrEMBL

UniProt Splice Variant

Entrez Gene

11102

UniGene

Hs.670654

RefSeq

NP_001092253

HUGO

HGNC:30327

OMIM

606112

CCDS

CCDS2888

HPRD

18001

IMGT

EMBL

AF001175 AK311969 BC002441 BC007342 BC012017 CR407611

GenPept

AAD00892 AAH02441 AAH07342 AAH12017 BAG34908 CAG28539